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Nanoparticles

The Topas nanoparticles are small polymer-coated superparamagnetic iron oxide particles (SPIONS) conjugated with disease-relevant peptides. They are efficiently taken up into endosomal compartments of liver sinusoidal endothelial cells (LSECs).

In proof of concept studies using murine experimental autoimmune encephalomyelitis, a model of multiple sclerosis, a single intravenous injection of nanoparticles loaded with neuroantigen peptides potently protected from disease development and ameliorated established disease.

Thus, T cell-specific peptide antigen-loaded nanoparticles represent promising therapeutic agents for many immune-mediated diseases.

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Nanoparticles

The Topas nanoparticles are small polymer-coated superparamagnetic iron oxide particles (SPIONS) conjugated with disease-relevant peptides. They are efficiently taken up into endosomal compartments of liver sinusoidal endothelial cells (LSECs).

In proof of concept studies using murine experimental autoimmune encephalomyelitis, a model of multiple sclerosis, a single intravenous injection of nanoparticles loaded with neuroantigen peptides potently protected from disease development and ameliorated established disease.

Thus, T cell-specific peptide antigen-loaded nanoparticles represent promising therapeutic agents for many immune-mediated diseases.