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Management Team

Topas Therapeutics is led by a highly qualified team with scientific depth and decades of experience in drug development and operational management.

 
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Klaus Martin, PhD, Chief Executive Officer

Klaus joined Topas Therapeutics in August 2020. He previously was President of Toronto-based Apobiologix, Apotex’ biotechnology division, where he led the development, sales & marketing and operational organization and played a key role in Apobiologix’ registrations, partnerships and in achieving a market leadership position. Prior to that, he was Chief Scientific Officer of Polpharma Biologics, where he set up the organization and managed all portfolio, licensing and late-stage development activities for biosimilar and innovative biologics. Previously, he worked at Sandoz Biopharmaceuticals, both in Germany and Austria, most recently serving as Global Head Business Development & Licensing (BD&L) and Portfolio Management where he drove the portfolio strategy and managed all licensing negotiations. Klaus holds a PhD in molecular genetics from Cambridge University and Darwin College, United Kingdom.

 
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Klaus Martin, PhD, Chief Executive Officer

Klaus joined Topas Therapeutics in August 2020. He previously was President of Toronto-based Apobiologix, Apotex’ biotechnology division, where he led the development, sales & marketing and operational organization and played a key role in Apobiologix’ registrations, partnerships and in achieving a market leadership position. Prior to that, he was Chief Scientific Officer of Polpharma Biologics, where he set up the organization and managed all portfolio, licensing and late-stage development activities for biosimilar and innovative biologics. Previously, he worked at Sandoz Biopharmaceuticals, both in Germany and Austria, most recently serving as Global Head Business Development & Licensing (BD&L) and Portfolio Management where he drove the portfolio strategy and managed all licensing negotiations. Klaus holds a PhD in molecular genetics from Cambridge University and Darwin College, United Kingdom.

 
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John Pohlner, PhD, Chief Operating Officer

John is co-founder and COO of Topas Therapeutics, where he focuses on the translation of academic innovation into industrial application. Over the past two decades, he held positions with a similar focus at Bionamics GmbH, Evotec Neurosciences GmbH and Evotec AG. Before that he studied and taught biology at major research institutes in Germany, receiving his PhD in biology at Heidelberg University and gaining habilitation at Tübingen University.

 
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John Pohlner, PhD, Chief Operating Officer

John is co-founder and COO of Topas Therapeutics, where he focuses on the translation of academic innovation into industrial application. Over the past two decades, he held positions with a similar focus at Bionamics GmbH, Evotec Neurosciences GmbH and Evotec AG. Before that he studied and taught biology at major research institutes in Germany, receiving his PhD in biology at Heidelberg University and gaining habilitation at Tübingen University.

 
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Reinaldo Digigow, PhD, Head of Nanotechnology & Head of CMC

Reinaldo focuses on nanoparticle design and synthesis, on analytics and on the strategy and execution of CMC-relevant drug product development at Topas Therapeutics. He has worked at pharmaceutical companies and analytical chemistry labs in Brazil and Europe. Before joining Topas, Reinaldo was Lab Head Analytical Development, CMC Center Europe at Takeda Pharmaceuticals. He was trained as a pharmacist and biochemist and received his PhD from the University of Fribourg, Switzerland.

 
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Reinaldo Digigow, PhD, Head of Nanotechnology & Head of CMC

Reinaldo focuses on nanoparticle design and synthesis, on analytics and on the strategy and execution of CMC-relevant drug product development at Topas Therapeutics. He has worked at pharmaceutical companies and analytical chemistry labs in Brazil and Europe. Before joining Topas, Reinaldo was Lab Head Analytical Development, CMC Center Europe at Takeda Pharmaceuticals. He was trained as a pharmacist and biochemist and received his PhD from the University of Fribourg, Switzerland.

 
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Sabine Fleischer, MD, Head of Translational Medicine

Sabine joined Topas Therapeutics in November 2015 as Head of Translational Medicine. Since 2009, she has been Scientific Coordinator of the Institute of Neuroimmunology and Multiple Sclerosis in Hamburg, focusing on translational research projects and early clinical MS studies in the framework of the research consortium NEU. Sabine studied medicine at the Universities of Giessen, Göttingen and Würzburg. As a scholar of the German Research Foundation, she trained in molecular biology and immunology at the Institute of Biochemistry in Munich and the Basel Institute for Immunology and was a postdoc at the Institute of Immunology in Ulm.

 
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Sabine Fleischer, MD, Head of Translational Medicine

Sabine joined Topas Therapeutics in November 2015 as Head of Translational Medicine. Since 2009, she has been Scientific Coordinator of the Institute of Neuroimmunology and Multiple Sclerosis in Hamburg, focusing on translational research projects and early clinical MS studies in the framework of the research consortium NEU. Sabine studied medicine at the Universities of Giessen, Göttingen and Würzburg. As a scholar of the German Research Foundation, she trained in molecular biology and immunology at the Institute of Biochemistry in Munich and the Basel Institute for Immunology and was a postdoc at the Institute of Immunology in Ulm.

 
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Barbara Metzler, PhD, Head of Biology

Barbara has over 25 years of experience in immune tolerance and immune regulation research in academia and industry. Before joining Topas Therapeutics, she led a research lab and numerous projects in autoimmunity and transplantation at Novartis. Her postgraduate and postdoctoral studies were related to T cell regulation, with an early focus on peptide-induced tolerance in models of autoimmunity. Barbara has a BSc (Hons) in biochemistry from Edinburgh University and a PhD in immunology from the University of Cambridge.

 
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Barbara Metzler, PhD, Head of Biology

Barbara has over 25 years of experience in immune tolerance and immune regulation research in academia and industry. Before joining Topas Therapeutics, she led a research lab and numerous projects in autoimmunity and transplantation at Novartis. Her postgraduate and postdoctoral studies were related to T cell regulation, with an early focus on peptide-induced tolerance in models of autoimmunity. Barbara has a BSc (Hons) in biochemistry from Edinburgh University and a PhD in immunology from the University of Cambridge.