Leveraging the natural tolerance induction capabilities of the liver.
Topas’ technology platform induces antigen-specific immune tolerance by utilizing the liver’s natural immunology capabilities. We target liver sinusoidal endothelial cells (LSECs), which generate tolerance against bloodborne antigens. Topas’ peptide-loaded nanoparticles mimic such bloodborne antigens and follow their natural processing in LSECs, including the generation of long-lasting antigen-specific regulatory T-cells (Tregs). This allows us to develop novel therapeutic solutions for autoimmune diseases, allergies and anti-drug antibodies.