Antigen-specific Induction of Immune Tolerance
The goal of Topas (Tolerizing Particles) is to develop novel therapeutics to treat a variety of immune-mediated and autoimmune diseases. The Topas approach harnesses the natural mechanisms of the liver to promote immune tolerance to blood borne antigens. Small peptide-loaded nanoparticles mimic such blood borne antigens and are taken up by liver sinusoidal endothelial cells (LSECs). LSECs present these antigens to T cells under anti-inflammatory conditions conducive to the induction of tolerogenic regulatory T cells (Tregs).
Tregs are pivotal for immune tolerance, and their therapeutic generation serves to re-instate healthy immune homeostasis and provide a cure for diseases characterized by undesirable or dysregulated inflammatory immune reactions.