Leveraging the natural tolerance induction capabilities of the liver.

Topas’ technology platform induces antigen-specific immune tolerance by utilizing the liver’s natural immunology capabilities. We target liver sinusoidal endothelial cells (LSECs), which generate tolerance against bloodborne antigens. Topas’ peptide-loaded nanoparticles mimic such bloodborne antigens and follow their natural processing in LSECs, including the generation of long-lasting antigen-specific regulatory T-cells (Tregs). This allows us to develop novel therapeutic solutions for autoimmune diseases, allergies and anti-drug antibodies.

Latest News

2018-01-25 – Press release

Topas Therapeutics serves as exclusive translational partner for Collaborative Research Center focused on liver inflammation at University Medical Center Hamburg-Eppendorf

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2017-11-02 – Press release

Topas Therapeutics extends its Series A to EUR 18 Million (USD 21 Million) with Boehringer Ingelheim Venture Fund

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2017-10-26 – Press release

Topas Therapeutics Appoints Rupert Sandbrink, M.D., Ph.D., as Chief Development Officer and Chief Medical Officer

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