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Nanoparticles

The Topas nanoparticles are small polymer-coated superparamagnetic iron oxide particles (SPIONS) conjugated with disease-relevant peptides. They are efficiently taken up into endosomal compartments of liver sinusoidal endothelial cells (LSECs). Topas continuously drives the further development of its nanoparticles, e.g. in the project “Optimizing of tolerance inducing particles (OpToPas)” funded by the European Regional Development Fund (EFRE) and the Free and Hanseatic City of Hamburg. For more details see PDF below.

In proof of concept studies using murine experimental autoimmune encephalomyelitis, a model of multiple sclerosis, a single intravenous injection of nanoparticles loaded with neuroantigen peptides potently protected from disease development and ameliorated established disease.

Thus, T cell-specific peptide antigen-loaded nanoparticles represent promising therapeutic agents for many immune-mediated diseases.

Bild

Nanoparticles

The Topas nanoparticles are small polymer-coated superparamagnetic iron oxide particles (SPIONS) conjugated with disease-relevant peptides. They are efficiently taken up into endosomal compartments of liver sinusoidal endothelial cells (LSECs). Topas continuously drives the further development of its nanoparticles, e.g. in the project “Optimizing of tolerance inducing particles (OpToPas)” funded by the European Regional Development Fund (EFRE) and the Free and Hanseatic City of Hamburg. For more details see PDF below.

In proof of concept studies using murine experimental autoimmune encephalomyelitis, a model of multiple sclerosis, a single intravenous injection of nanoparticles loaded with neuroantigen peptides potently protected from disease development and ameliorated established disease.

Thus, T cell-specific peptide antigen-loaded nanoparticles represent promising therapeutic agents for many immune-mediated diseases.