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Topas Particle Conjugates

Topas Particle Conjugates (TPCs) are small polymer-coated superparamagnetic iron oxide particles (SPIONS) conjugated with disease-relevant peptides. They are efficiently taken up into endosomal compartments of liver sinusoidal endothelial cells (LSECs). The fast and active uptake of circulating TPCs by LSECs leads to rapid clearance of the particles from the bloodstream, allows an exact dosing of the antigen residing in the liver and avoids undesired immune reactions. TPCs provide major competitive advantages, including in vivo traceability, dose-ability, biodegradability and scalability along GMP requirements. Proof-of-concept of Topas’ technology platform has been established in several mouse models; pre-clinical testing in other models is underway. TPCs are covered by solid IP with rights to future IP already secured.

    Topas Particle Conjugates

    Topas Particle Conjugates (TPCs) are small polymer-coated superparamagnetic iron oxide particles (SPIONS) conjugated with disease-relevant peptides. They are efficiently taken up into endosomal compartments of liver sinusoidal endothelial cells (LSECs). The fast and active uptake of circulating TPCs by LSECs leads to rapid clearance of the particles from the bloodstream, allows an exact dosing of the antigen residing in the liver and avoids undesired immune reactions. TPCs provide major competitive advantages, including in vivo traceability, dose-ability, biodegradability and scalability along GMP requirements. Proof-of-concept of Topas’ technology platform has been established in several mouse models; pre-clinical testing in other models is underway. TPCs are covered by solid IP with rights to future IP already secured.